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Scientists Target Human Stomach Cells for Diabetes Therapy
Stem cells from the human stomach can be converted into cells that secrete insulin in response to rising blood sugar levels, offering a promising approach to treating diabetes, according to a preclinical study from researchers at Weill Cornell Medicine.
Too Much Insulin Can Be As Dangerous As Too Little
One hundred years of research have greatly advanced medical and biochemical understanding of how insulin works and what happens when it is lacking, but the reverse, how potentially fatal insulin hyper-responsiveness is prevented, has remained a persistent mystery. In a new study, published in the April 20, 2023 online edition of Cell Metabolism, a team of scientists at the University of California San Diego School of Medicine, with colleagues elsewhere, describe a key player in the defense mechanism that safeguards us against excessive insulin in the body.
Can Lab-Grown Beta Cells Revolutionize Diabetes Care?
Since the 1970s, clinicians have known that people with type 1 diabetes can be treated by transplanting pancreatic islets – clusters of insulin-producing “beta cells” – from a healthy organ donor. The procedure, however, is limited by a shortage of donors. The renowned diabetes researcher Douglas Melton, PhD, at Harvard University, leads a group that developed a way to increase islet supplies by generating pancreatic beta cells in the lab from stem cells. Today, researchers and scientists refine this process by coaxing stem cells to reliably develop into functional beta cells that can be transplanted into patients to produce insulin.